Twenty-sixth century civilization teeters on the brink with Earth a radioactive ruin. The fragile world government has outlawed mutants – humans whose genes have gone wrong – and placed bounties on their heads.

Leon Miller, one of a handful of bounty hunters who makes a living tracking down mutants, hunts the last of the Ten Most Wanted, a mutant known simply as “Number Six.” Despite a record high bounty, Miller’s real motivation is to find the woman, a human who has taken up with Number Six.

From the decaying ruins of New York City, across the ambush-laden freak-filled outlands, and into the flesh-flaying storms of the Pacific Ditch, the dangerous pursuit unfolds.

Complicating matters, the government has hired Ben Trills – a cold-blooded mercenary – to kill Number Six and all of his entourage. His strategy is simple. Shadow Miller, let him do the dirty work of flushing Number Six, then take the clean shot. And if Miller gets in the way…