DARKHOLD sees Doctor Doom unearth the ancient Darkhold, a text written by the elder god Chthon, and unintentionally opening a passageway for Chthon to return to our dimension. To stop him, the Scarlet Witch recruits five heroes-Iron Man, Wasp (Janet), Black Bolt, Spider-Man (Peter), and Blade. To enter Chthon's dimension and fight him, the heroes must read from the Darkhold, which drives them insane.

Collects The Darkhold Alpha (2021) #1, The Darkhold: Blade (2021) #1, The Darkhold: Wasp (2021) #1, The Darkhold: Iron Man (2021) #1, The Darkhold: Black Bolt (2021) #1, The Darkhold: Spider-Man (2021) #1, The Darkhold Omega (2020) #1.