Expanded information on agents that are seen with increasing frequency in poisoned patients, including lamotrigine and pregabalin Updated detail on the management of agents including direct oral anticoagulants, digoxin, desvenlafaxine and corrosives Updated and standardised treatment recommendations for dysrhythmias, particularly resulting from drug-induced conduction abnormalities (QRS and QT prolongation) Simplified and standardised approaches to management (particularly cardiovascular toxicity from a variety of agents)