Gülse Birsel is a Turkish comedian, writer, screenwriter and actress.

She attended Beyoğlu Anadolu High school and got a degree in economics at Boğaziçi University. She started working for Aktüel magazine as a correspondent in her second year as an undergraduate. Finally, she graduated from Boğaziçi University as an economist and began working for Aktüel magazine as an editor in 1994. She went to New York and studied for a master's degree in the film program of Columbia University's School of the Arts.

She was first noticed through her articles in Turkish newspapers, titled "Metropol Manzaraları" (Views of the Metropolis, "Metropolis" is actually Istanbul), with her easily noticed funny touches of city life. She later presented a comedy show named "G.A.G.". Between 2004-2009, she was the screenwriter of the sitcom Avrupa Yakası, where she also played one of the leading roles. As of 2012, she is scripting and starring in a new sitcom, Yalan Dünya. She writes weekly for Sabah.